Background Treatment with tumor-targeted toxins attempts to overcome the disadvantages
of conventional cancer therapies by directing a drug's cytotoxic effect specifically towards …

Protein-based targeted toxins play an increasingly important role in targeted tumor
therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major …

Targeted cancer therapy provides the basis for the arrest of tumor growth in aggressive
pancreatic carcinoma; however, a number of protein‐based targeted toxins lack efficacy due …

The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the
target cell to mediate its fatal effect. Although more than 500 targeted toxins have been …

Targeted cancer therapies have been extensively tested with the purpose to selectively
suppress tumor growth and to avoid harming healthy tissue. However, failure to escape …

Targeted toxins are protein-based therapeutics under investigation for their usage in
targeted tumor therapies. They are composed of a toxic enzyme, such as the ribosome …

Two of the main problems associated with administration of receptor-targeted toxins in tumor
therapy are severe systemic side effects and low transfer of the toxins into the cytosol after …

Drug Delivery in Oncology: From Basic Research to Cancer Therapy: Design of Targeted Protein
Toxins Page 1 1443 45 Design of Targeted Protein Toxins Hendrik Fuchs and Christopher …

Targeted anti-tumor toxins consist of a toxic functional moiety that is chemically linked or
recombinantly fused to a cell-directing ligand. Ribosome-inactivating proteins (RIPs) …

Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic
effect once they have escaped from the endosomes or lysosomes. In this study, the reporters …