Specific, tight-binding protein partners are valuable helpers to facilitate membrane protein
(MP) crystallization, because they can i) stabilize the protein, ii) reduce its conformational …

Because of the importance of their physiological functions, cell membranes represent critical
targets in biological research. Membrane proteins, which make up≈ 1/3 of the proteome …

Amphipols are amphipathic polymers that stabilize membrane proteins isolated from their
native membrane. They have been functionalized with various chemical groups in the past …

Amphipols (APols) are short amphipathic polymers that stabilize membrane proteins (MPs)
in aqueous solutions. In the present study, A8–35, a polyacrylate-based APol, was grafted …

Amphipols (APols) have become important tools for the stabilization, folding, and in vitro
structural and functional studies of membrane proteins (MPs). Direct crystallization of MPs …

Membrane proteins (MPs) are important pharmacological targets because of their
involvement in many essential cellular processes whose dysfunction can lead to a large …

Amphipathic polymers called amphipols provide a valuable alternative to detergents for
keeping integral membrane proteins soluble in aqueous buffers. Here, we characterize …

This book is the first to be entirely devoted to the challenging art of handling membrane
proteins out of their natural environment, a key process in biological and pharmaceutical …

Among the major obstacles to pharmacological and structural studies of integral membrane
proteins (MPs) are their natural scarcity and the difficulty in overproducing them in their …

As traditional detergents might destabilize or even denature membrane proteins,
amphiphilic polymers have moved into the focus of membrane-protein research in recent …