Glutamate measurements using edited MRS

MG Saleh, A Prescot, L Chang, C Cloak… - Magnetic resonance …, 2024 - Wiley Online Library
Purpose To demonstrate J‐difference coediting of glutamate using Hadamard encoding and
reconstruction of Mescher‐Garwood‐edited spectroscopy (HERMES). Methods Density …

Phase‐adjusted echo time (PATE)‐averaging 1H MRS: application for improved glutamine quantification at 2.89 T

AP Prescot, T Richards, SR Dager, C Choi… - NMR in …, 2012 - Wiley Online Library
1H MRS investigations have reported altered glutamatergic neurotransmission in a variety of
psychiatric disorders. The unraveling of glutamate from glutamine resonances is crucial for …

Effects of noise and linewidth on in vivo analysis of glutamate at 3 T

Y Zhang, J Shen - Journal of Magnetic Resonance, 2020 - Elsevier
Magnetic resonance spectroscopy (MRS) can noninvasively detect metabolites in vivo,
including glutamate (Glu). However, quantification is known to be affected by the overlaps …

Optimized MEGA‐SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T

M Craveiro, C Cudalbu, V Mlynárik… - NMR in …, 2014 - Wiley Online Library
Glutamine has multiple roles in brain metabolism and its concentration can be altered in
various pathological conditions. An accurate knowledge of its concentration is therefore …

Feasibility of glutamate and GABA detection in pons and thalamus at 3T and 7T by proton magnetic resonance spectroscopy

S Younis, A Hougaard, CE Christensen… - Frontiers in …, 2020 - frontiersin.org
Glutamate detection in pons and thalamus using proton magnetic resonance spectroscopy
(1H-MRS) after an intervention is of interest for studying various brain disorders. However …

Homonuclear J‐refocused spectral editing technique for quantification of glutamine and glutamate by 1H NMR spectroscopy

HK Lee, A Yaman, O Nalcioglu - Magnetic resonance in …, 1995 - Wiley Online Library
Quantification of the excitatory amino acid of glutamine and glutamate is extremely important
partly because, when in excessive amounts, they can produce neuronal damage. However …

The case of the missing glutamine

I Hancu, J Port - NMR in Biomedicine, 2011 - Wiley Online Library
A theoretical study was performed to determine the accuracy and repeatability of multiple
one‐dimensional pulse sequences in the quantification of glutamine concentration at 3 T …

Optimized in vivo brain glutamate measurement using long‐echo‐time semi‐LASER at 7 T

D Wong, AL Schranz, R Bartha - NMR in Biomedicine, 2018 - Wiley Online Library
A short echo time (TE) is commonly used for brain glutamate measurement by 1H MRS to
minimize drawbacks of long TE such as signal modulation due to J evolution and T2 …

Localized MRS reliability of in vivo glutamate at 3 T in shortened scan times: a feasibility study

JE Jensen, RP Auerbach, A Pisoni… - NMR in …, 2017 - Wiley Online Library
Glutamate is the prime excitatory neurotransmitter in the mammalian brain and has been
implicated in a wide range of psychiatric conditions. To improve the applicability and clinical …

[PDF][PDF] Separate signal detection of glutamate and glutamine in the rat brain in vivo at 4.7 T using optimized 1H-CT-PRESS with effective homonuclear decoupling

W Dreher, D Leibfritz - Proceedings of the 6th Annual Meeting of …, 1998 - cds.ismrm.org
Besides the signal-to-noise ratio (SNR) per constant total measuring time Tmeas, the quality
of signal separation and peak assignment is of central importance for the value of in vivo'H …