Abstract A CT‐PRESS sequence was implemented on a 3‐T MR scanner and optimized for
the detection of the C4 resonance of glutamate. By simulating the sequence using the full …

Three-dimensional image-selected in vivo spectroscopy (ISIS) was combined with phase-
cycled 1H–15N heteronuclear multiple-quantum coherence (HMQC) transfer NMR for …

Glutamate is an important neurotransmitter. Although many studies have measured
glutamate concentration in vivo using magnetic resonance spectroscopy (MRS), researchers …

Purpose To improve the detection and subsequent estimation of the diffusion properties of
strongly J‐coupled metabolites in diffusion‐weighted MRS (DWS). Methods A new …

Abstract 2D NMR 1 H–X (X= 15 N or 13 C) HSQC spectra contain cross-peaks for all XH n
moieties. Multiplicity-edited 1 H–13 C HSQC pulse sequences generate opposite signs …

Mapping of a major antioxidant, glutathione (GSH), was achieved in the human brain in vivo
using a doubly‐selective multiple quantum filtering based chemical shift imaging (CSI) of …

13C spectroscopy combined with the injection of 13C-labeled substrates is a powerful
method for the study of brain metabolism in vivo. Since highly localized measurements are …

Edited MRS allows the detection of low-concentration metabolites, whose signals are not
resolved in the MR spectrum. Tailored acquisitions can be designed to detect, for example …

The proton NMR transverse relaxation time T2 of glutamate (Glu) in human brain was
measured by means of spectrally selective refocusing at 3.0 T in vivo. An 81.4‐ms‐long dual …

B1 inhomogeneity and chemical shift displacement error (CSDE) increase with the main
magnetic field strength and are therefore deleterious for magnetic resonance spectroscopy …