Purpose Glutathione (GSH) is an important intracellular antioxidant in the brain. A number of
studies report its measurement by localized 1 H spectroscopy using PRESS and STEAM …

Selectively studying parts of proteins and metabolites in tissue with nuclear magnetic
resonance promises new insights into molecular structures or diagnostic approaches …

The determination of carbon multiplicities is essential for In this work, we show how the PEP
methodology can be successfully implemented in 1D and 2D pulse sequences in the …

The J-coupled proton metabolites which have well separated multiplets have been identified
by one-dimensional spectralediting techniques. A major drawback is that only one …

[5-13C, 15N] Glutamine, with 1J (13C–15N) of 16 Hz, was observed in vivo in the brain of
spontaneously breathing rats by 13C MRS at 4.7 T. The brain [5-13C] glutamine peak …

Purpose: To identify the pulse sequence and acquisition parameters that result in the most
accurate and repeatable measurements of glutamate (Glu) concentration in the brain at 3T …

Several different pathologies, including many neurodegenerative disorders, affect the
energy metabolism of the brain. Glutamate, a neurotransmitter in the brain, can be used as a …

Purpose To determine the reproducibility of a comprehensive single‐session measurement
of glutathione (GSH), γ‐aminobutyric acid (GABA), glutamate, and other biochemicals …

The feasibility of selective in vivo detection of glutathione (l‐γ‐glutamyl‐l‐cysteinyl‐glycine,
GSH) in the human brain by means of 1H magnetic resonance spectroscopy (MRS) at 1.5 T …

A single voxel proton NMR double quantum filter (DQF) for measurement of glutathione
(GSH) in human brain at 3T is reported. Yield enhancement for the CH2 resonances of the …