Current trends in inflammatory and immunomodulatory mediators in sepsis
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …
[HTML][HTML] Cytokines in sepsis: potent immunoregulators and potential therapeutic targets—an updated view
W Schulte, J Bernhagen, R Bucala - Mediators of inflammation, 2013 - hindawi.com
Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …
Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses
Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Cellular mechanisms in sepsis
E Jean-Baptiste - Journal of intensive care medicine, 2007 - journals.sagepub.com
Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …
system as a result of an uncontrolled response to infection. Septic patients show …
Inflammation and cell death of the innate and adaptive immune system during sepsis
C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …
or abnormal immune response to overwhelming infection. It is now widely accepted that …
The significance and regulatory mechanisms of innate immune cells in the development of sepsis
YY Luan, N Dong, M Xie, XZ Xiao… - Journal of Interferon & …, 2014 - liebertpub.com
Sepsis with subsequent multiple organ dysfunction is a pronounced systemic inflammatory
response to concealed or known infection and is a leading cause of death in intensive care …
response to concealed or known infection and is a leading cause of death in intensive care …
Harmful molecular mechanisms in sepsis
D Rittirsch, MA Flierl, PA Ward - Nature Reviews Immunology, 2008 - nature.com
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …
Targeting macrophage immunometabolism: Dawn in the darkness of sepsis
V Kumar - International Immunopharmacology, 2018 - Elsevier
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …
Advancement in modern medicine and establishment of separate branches of medical …