Current trends in inflammatory and immunomodulatory mediators in sepsis

M Aziz, A Jacob, WL Yang, A Matsuda… - Journal of leukocyte …, 2013 - academic.oup.com
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

[HTML][HTML] Cytokines in sepsis: potent immunoregulators and potential therapeutic targets—an updated view

W Schulte, J Bernhagen, R Bucala - Mediators of inflammation, 2013 - hindawi.com
Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses

A Matsuda, A Jacob, R Wu, M Aziz… - Journal of Nippon …, 2012 - jstage.jst.go.jp
Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Cellular mechanisms in sepsis

E Jean-Baptiste - Journal of intensive care medicine, 2007 - journals.sagepub.com
Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …

Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside

Z Doganyigit, E Eroglu, E Akyuz - Human & experimental …, 2022 - journals.sagepub.com
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …

Inflammation and cell death of the innate and adaptive immune system during sepsis

C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

The significance and regulatory mechanisms of innate immune cells in the development of sepsis

YY Luan, N Dong, M Xie, XZ Xiao… - Journal of Interferon & …, 2014 - liebertpub.com
Sepsis with subsequent multiple organ dysfunction is a pronounced systemic inflammatory
response to concealed or known infection and is a leading cause of death in intensive care …

Harmful molecular mechanisms in sepsis

D Rittirsch, MA Flierl, PA Ward - Nature Reviews Immunology, 2008 - nature.com
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …

Targeting macrophage immunometabolism: Dawn in the darkness of sepsis

V Kumar - International Immunopharmacology, 2018 - Elsevier
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …