The puzzle of sepsis: fitting the pieces of the inflammatory response with treatment

J Cunneen, M Cartwright - AACN Advanced Critical Care, 2004 - AACN
Sepsis is a complex syndrome characterized by simultaneous activation of inflammation and
coagulation in response to microbial insult. These events manifest as systemic inflammatory …

[HTML][HTML] Sepsis and septic shock: current treatment strategies and new approaches

G Polat, RA Ugan, E Cadirci, Z Halici - The Eurasian journal of …, 2017 - ncbi.nlm.nih.gov
Sepsis is a complex condition characterized by the simultaneous activation of inflammation
and coagulation in response to microbial insult. These events manifest as systemic …

The 'cytokine profile': a code for sepsis

L Ulloa, KJ Tracey - Trends in molecular medicine, 2005 - cell.com
Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …

T cells are potent early mediators of the host response to sepsis

KR Kasten, J Tschöp, SG Adediran, DA Hildeman… - Shock, 2010 - journals.lww.com
The complex immune response associated with sepsis results in a high rate of morbidity and
mortality, despite substantial basic science and clinical advances. Most of the research has …

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 …

AC Patera, AM Drewry, K Chang… - Journal of Leucocyte …, 2016 - academic.oup.com
Sepsis is a heterogeneous syndrome comprising a highly diverse and dynamic mixture of
hyperinflammatory and compensatory anti-inflammatory immune responses. This immune …

Organ dysfunction as a new standard for defining sepsis

S Fujishima - Inflammation and Regeneration, 2016 - Springer
Despite advances in intensive care and the widespread use of standardized care included
in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and …

Sepsis und Multiorganversagen–Pathophysiologie der Sepsis

F Uhle, C Lichtenstern, T Brenner… - AINS-Anästhesiologie …, 2015 - thieme-connect.com
Unser Verständnis der Ursachen und pathophysiologischen Grundlagen der Sepsis war im
Laufe der Zeit einem stetigen Wandel unterworfen. Nach heutigem Verständnis handelt es …