Peptide-conjugated nanoparticles reduce positive co-stimulatory expression and T cell activity to induce tolerance
Targeted approaches to treat autoimmune diseases would improve upon current therapies
that broadly suppress the immune system and lead to detrimental side effects. Antigen …
that broadly suppress the immune system and lead to detrimental side effects. Antigen …
PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance
The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …
promise for treating autoimmune diseases. While PEGylation has been widely used to …
Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide-co-glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance
LM Casey, RM Pearson, KR Hughes… - Bioconjugate …, 2017 - ACS Publications
Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …
A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease
Z Hunter, DP McCarthy, WT Yap, CT Harp, DR Getts… - ACS …, 2014 - ACS Publications
Targeted immune tolerance is a coveted therapy for the treatment of a variety of autoimmune
diseases, as current treatment options often involve nonspecific immunosuppression …
diseases, as current treatment options often involve nonspecific immunosuppression …
An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy
DP McCarthy, JWT Yap, CT Harp, WK Song… - … , Biology and Medicine, 2017 - Elsevier
Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
Controlled delivery of single or multiple antigens in tolerogenic nanoparticles using peptide-polymer bioconjugates
RM Pearson, LM Casey, KR Hughes, LZ Wang… - Molecular Therapy, 2017 - cell.com
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …
specific immunological tolerance in multiple immune models and are at various stages of …
Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation
Allogeneic cell therapies have either proven effective or have great potential in numerous
applications, though the required systemic, life-long immunosuppression presents …
applications, though the required systemic, life-long immunosuppression presents …
Nanoparticle dose and antigen loading attenuate antigen‐specific T‐cell responses
Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …
rejection are treated with therapeutics that suppress the immune system, and the lack of …
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance
RA Maldonado, RA LaMothe… - Proceedings of the …, 2015 - National Acad Sciences
Current treatments to control pathological or unwanted immune responses often use broadly
immunosuppressive drugs. New approaches to induce antigen-specific immunological …
immunosuppressive drugs. New approaches to induce antigen-specific immunological …
Biodegradable nanoparticle delivery of a Th2‐biased peptide for induction of Th1 immune responses
MEC Lutsiak, GS Kwon… - Journal of pharmacy and …, 2006 - Wiley Online Library
The type of immune response developed against the hepatitis B virus (HBV) is crucial in
determining the outcome of the disease. The protective effects of vaccine‐induced antibody …
determining the outcome of the disease. The protective effects of vaccine‐induced antibody …