Background—AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that
works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK …

Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of
vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings …

Introduction• AMPK structure and function• Role of AMPK in the heart• Role of AMPK in
endothelial cells• Role of AMPK in vascular smooth muscle cells• Role of AMPK in vascular …

AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme
that regulates cell metabolism. Emerging evidence indicates that AMPK also plays an …

Vascular smooth muscle cell (VSMC) activation promotes a synthetic phenotype that
underlies many vessel growth disorders. In this regard it has been suggested that the …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …

AMP-activated protein kinase (AMPK) is regulated by various cellular stresses. Vascular
endothelial growth factor (VEGF), a key regulator of angiogenesis, is also upregulated by …

AMP-activated protein kinase (AMPK) is a sensor of cellular energy state and a regulator of
cellular homeostasis. In endothelial cells, AMPK is stimulated via the upstream kinases …

SUMMARY 1 AMP‐activated protein kinase (AMPK) is a serine/threonine protein kinase
involved in the regulation of cellular and organismal metabolism. AMPK has a heterotrimeric …

Vasodilatation is a vital mechanism of systemic blood flow regulation that occurs during
periods of increased energy demand. The AMP‐dependent protein kinase (AMPK) is a …