Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide

SM Krasnow, JG Hohmann, A Gragerov… - …, 2004 - karger.com
Galanin-like peptide (GALP) shares partial sequence identity with galanin and exhibits
agonistic activity at two of the galanin receptor subtypes (GALR1 and GALR2) in vitro. The …

Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 …

D Wynick, DM Smith, M Ghatei… - Proceedings of the …, 1993 - National Acad Sciences
Structure-activity studies demonstrate that galanin fragments 1-15 and 2-29 are fully active,
whereas fragment 3-29 has been reported to be inactive, in a number of different in vivo …

Galanin-like peptide stimulates food intake in the rat

Y Matsumoto, T Watanabe, Y Adachi, T Itoh, T Ohtaki… - Neuroscience …, 2002 - Elsevier
We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for
galanin receptor subtype GalR2. To investigate the physiological role of GALP, we …

Galanin-like peptide mRNA in neural lobe of rat pituitaryIncreased expression after osmotic stimulation suggests a role for galanin-like peptide in neuron-glial …

J Shen, JA Larm, AL Gundlach - Neuroendocrinology, 2001 - karger.com
Galanin-like peptide (GALP) was recently identified in the porcine hypothalamus, pituitary
gland and gut, and has reported selectivity for the GalR2, cf the GalR1 receptor. GALP …

Identification and biochemical characterization of the human brain galanin receptor

R Walli, H Schäfer, C Morys-Wortmann… - Journal of …, 1994 - jme.bioscientifica.com
Human galanin (hGal) is an important neuro-modulator present in the brain, gastrointestinal
system and the hypothalamo-pituitary axis. A specific receptor for hGal has been identified in …

Galanin and the neuroendocrine axes

I Merchenthaler - Galanin, 2010 - Springer
Galanin has diverse physiological functions, including nociception, arousal/sleep regulation,
cognition, and many aspects of neuroendocrine activities that are associated with feeding …

Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3

LF Kolakowski Jr, GP O'Neill, AD Howard… - Journal of …, 1998 - Wiley Online Library
Galanin is a 29‐or 30‐amino acid peptide with wide‐ranging effects on hormone release,
feeding behavior, smooth muscle contractility, and somatosensory neuronal function. Three …

Anxiogenic-like action of galanin after intra-amygdala administration in the rat

C Möller, W Sommer, A Thorsell, M Heilig - Neuropsychopharmacology, 1999 - Elsevier
The neuropeptide galanin is expressed in brain structures implicated in regulation of
emotionality. The amygdala is known to play a central role in mechanisms of fear and …

Hypothalamic galanin: control by signals of fat metabolism

J Wang, A Akabayashi, HJ Yu, J Dourmashkin… - Brain research, 1998 - Elsevier
The peptide, galanin (GAL), is known to stimulate eating behavior, reduce energy
expenditure and affect the release of metabolic hormones. Further, the activity of this peptide …

Galanin inhibits continuous and phasic firing in rat hypothalamic magnocellular neurosecretory cells

S Papas, CW Bourque - Journal of Neuroscience, 1997 - Soc Neuroscience
The effects of galanin (GAL) on magnocellular neurosecretory cells (MNCs) were examined
during microelectrode recordings from supraoptic neurons in superfused hypothalamic …