[HTML][HTML] Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply
H Zhang, C Li, D Wen, R Li, S Lu, R Xu, Y Tang, Y Sun… - Redox Biology, 2022 - Elsevier
In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …
coupling is crucial for the growth and development of competent oocytes as it mediates the …
[HTML][HTML] Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes
M Zhang, Y Lu, Y Chen, Y Zhang, B Xiong - Redox biology, 2020 - Elsevier
Age-related decline in female fertility is a common feature that occurs in the fourth decade of
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …
[HTML][HTML] Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression
Q Yang, S Dai, X Luo, J Zhu, F Li, J Liu, G Yao… - …, 2018 - rep.bioscientifica.com
The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …
as a result of the aging process. Melatonin is considered to be an anti-aging agent …
Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events
Melatonin is a well‐characterized antioxidant that has been successfully used to protect
oocytes from reactive oxygen species during in vitro maturation (IVM), resulting in improved …
oocytes from reactive oxygen species during in vitro maturation (IVM), resulting in improved …
[HTML][HTML] Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig
T Wang, YY Gao, L Chen, ZW Nie, W Cheng… - Aging (albany …, 2017 - ncbi.nlm.nih.gov
Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …
[HTML][HTML] Aging-related ovarian failure and infertility: melatonin to the rescue
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …
organ preceding the age-related deterioration in other tissues, with the middle-aged …
Applications of melatonin in female reproduction in the context of oxidative stress
Y Jiang, H Shi, Y Liu, S Zhao… - Oxidative medicine and …, 2021 - Wiley Online Library
Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …
affecting the oocyte quality and early embryo development. Improving oxidative stress is …
Melatonin maintains mitochondrial membrane potential and decreases excessive intracellular Ca2+ levels in immature human oocytes
YJ Liu, D Ji, ZB Liu, TJ Wang, FF Xie, ZG Zhang… - Life Sciences, 2019 - Elsevier
Aims Previous reports have demonstrated that melatonin exists in multiple extrapineal sites,
and higher amounts of melatonin are present in human follicular fluid than in serum, which …
and higher amounts of melatonin are present in human follicular fluid than in serum, which …
[HTML][HTML] Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice
C Song, W Peng, S Yin, J Zhao, B Fu, J Zhang, T Mao… - Scientific reports, 2016 - nature.com
Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …
oxidative damage. However, the protective effects of melatonin against ovarian aging has …
Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro
The quality of metaphase II oocytes deteriorates rapidly following ovulation as the result of
an aging process associated with impaired fertilizing potential, disrupted developmental …
an aging process associated with impaired fertilizing potential, disrupted developmental …
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