In brief Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as
abnormalities in offspring. This review provides an update on the contributions of oxidative …

Melatonin protects luteinized granulosa cells (GCs) from oxidative stress in the follicle during
ovulation. However, it is unclear in which cellular components (eg, nuclei, mitochondria, or …

Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …

Bisphenol A (BPA) is synthetic organic compound that exhibits estrogen-like properties and
it induces mitochondrial superoxide production. Melatonin (Mela) protects against BPA …

Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

Endometriosis an important cause of female infertility and seriously impact physical and
psychological health of patients. Endometriosis is now considered to be a public health …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Negative effects of postovulatory aging on fertilization ability and subsequent embryo
development have been reported in rodents; however, the molecular and cellular changes …

Poor‐quality oocytes (those with 1–2 layers of cumulus cells) typically possess low meiotic
competence and development. Prolonging the duration of in vitro maturation (IVM; 52 hr) …