Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment
Objective Early life nutrition is critical for the development of hypothalamic neurons involved
in energy homeostasis. We previously showed that intrauterine and early postnatal …
in energy homeostasis. We previously showed that intrauterine and early postnatal …
Maternal overnutrition impacts offspring adiposity and brain appetite markers‐modulation by postweaning diet
Maternal obesity has long‐term consequences for the development of hypothalamic
neurones involved in energy homeostasis and the metabolic profile in offspring. In the …
neurones involved in energy homeostasis and the metabolic profile in offspring. In the …
Differential responses of orexigenic neuropeptides to fasting in offspring of obese mothers
Maternal obesity due to long‐term high‐fat diet (HFD) consumption leads to faster growth in
offspring during suckling, and increased adiposity at 20 days of age. Decreased expression …
offspring during suckling, and increased adiposity at 20 days of age. Decreased expression …
Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism
Maternal obesity is increasing, and it is known that the intrauterine experience programs
fetal and newborn metabolism. However, the relative contributions of pre-or postnatal factors …
fetal and newborn metabolism. However, the relative contributions of pre-or postnatal factors …
Maternal obesity alters neurotrophin-associated MAPK signaling in the hypothalamus of male mouse offspring
I Bae-Gartz, R Janoschek, S Breuer… - Frontiers in …, 2019 - frontiersin.org
Purpose Maternal obesity has emerged as an important risk factor for the development of
metabolic disorders in the offspring. The hypothalamus as the center of energy homeostasis …
metabolic disorders in the offspring. The hypothalamus as the center of energy homeostasis …
Observations on the orexigenic hypothalamic neuropeptide Y‐system in neonatally overfed weanling rats
Plagemann, Harder, Rake, Waas… - Journal of …, 1999 - Wiley Online Library
Early postnatal overnutrition is a risk factor for obesity in juvenile and adult life. Underlying
pathophysiological mechanisms are still unclear. Hypothalamic neuropeptides are …
pathophysiological mechanisms are still unclear. Hypothalamic neuropeptides are …
Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation
RL Cripps, MS Martin-Gronert, ZA Archer… - Clinical …, 2009 - portlandpress.com
Epidemiological studies show a link between low birthweight and increased obesity. In
contrast, slow growth during the lactation period reduces obesity risk. The present study …
contrast, slow growth during the lactation period reduces obesity risk. The present study …
Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring
Epidemiological studies suggest that maternal undernutrition predisposes the offspring to
development of energy balance metabolic pathologies in adulthood. Using a model of a …
development of energy balance metabolic pathologies in adulthood. Using a model of a …
Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal …
A growing body of evidence suggests that maternal undernutrition sensitizes the offspring to
the development of energy balance metabolic disorders such as type 2 diabetes …
the development of energy balance metabolic disorders such as type 2 diabetes …
Developmental programming of hypothalamic neuronal circuits: impact on energy balance control
T Gali Ramamoorthy, G Begum, E Harno… - Frontiers in …, 2015 - frontiersin.org
The prevalence of obesity in adults and children has increased globally at an alarming rate.
Mounting evidence from both epidemiological studies and animal models indicates that …
Mounting evidence from both epidemiological studies and animal models indicates that …