Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized
variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional …
variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional …
Diagnosis of 'double hit'diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when …
SH Swerdlow - Hematology 2014, the American Society of …, 2014 - ashpublications.org
Identification of large B-cell lymphomas that are “extra-aggressive” and may require therapy
other than that used for diffuse large B-cell lymphoma, not otherwise specified (DLBCL …
other than that used for diffuse large B-cell lymphoma, not otherwise specified (DLBCL …
Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy
H Nyman, M Adde… - Blood, The Journal …, 2007 - ashpublications.org
Germinal center (GC) and non-GC phenotypes are predictors of outcome in diffuse large B-
cell lymphoma (DLBCL) and can be used to stratify chemotherapy-treated patients into low …
cell lymphoma (DLBCL) and can be used to stratify chemotherapy-treated patients into low …
The t (14; 18) is associated with germinal center-derived diffuse large B-cell lymphoma and is a strong predictor of outcome
SL Barrans, PAS Evans, SJM O'Connor, SJ Kendall… - Clinical cancer …, 2003 - AACR
Abstract The t (14; 18) is present in a significant proportion of diffuse large B-cell lymphomas
(DLBCLs), however, the prognostic effect of the translocation and the relationship with …
(DLBCLs), however, the prognostic effect of the translocation and the relationship with …
[HTML][HTML] Prognostic factors for diffuse large B-cell lymphoma in the R (X) CHOP era
Background The introduction of rituximab (R) to conventional CHOP chemotherapy for newly
diagnosed diffuse large B-cell lymphoma (DLBCL) led to an unequivocal improvement in …
diagnosed diffuse large B-cell lymphoma (DLBCL) led to an unequivocal improvement in …
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
JG Lohr, P Stojanov, MS Lawrence… - Proceedings of the …, 2012 - National Acad Sciences
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we
performed massively parallel whole-exome sequencing of 55 primary tumor samples from …
performed massively parallel whole-exome sequencing of 55 primary tumor samples from …
[HTML][HTML] Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma
B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically
distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B …
distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B …
Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas
IS Lossos, AA Alizadeh, MB Eisen… - Proceedings of the …, 2000 - National Acad Sciences
B cell diffuse large cell lymphoma (B-DLCL) is a heterogeneous group of tumors, based on
significant variations in morphology, clinical presentation, and response to treatment. Gene …
significant variations in morphology, clinical presentation, and response to treatment. Gene …
Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas
MJ Kluk, B Chapuy, P Sinha, A Roy, PD Cin… - PloS one, 2012 - journals.plos.org
Diffuse large B cell lymphoma (DLBCL) is a clinically and genetically heterogeneous
disease. A small subset of DLBCLs has translocations involving the MYC locus and an …
disease. A small subset of DLBCLs has translocations involving the MYC locus and an …
Genetic landscapes of relapsed and refractory diffuse large B-cell lymphomas
Purpose: Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of
patients, and yet little is known about its biology. Experimental Design: Using exome …
patients, and yet little is known about its biology. Experimental Design: Using exome …