Alcohol self‐administration: further examination of the role of dopamine receptors in the nucleus accumbens

CW Hodge, HH Samson… - Alcoholism: Clinical and …, 1997 - Wiley Online Library
One of the functions of the mesolimbic dopamine (DA) system is to regulate the process of
reinforcement, a process that is thought to influence drug self‐administration. This study …

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

F Weiss, MT Lorang, FE Bloom, GF Koob - Journal of Pharmacology and …, 1993 - ASPET
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in
ethanol reinforcement and genetically determined ethanol preference. This hypothesis was …

PRECLINICAL STUDY: Evidence for the role of dopamine D3 receptors in oral operant alcohol self‐administration and reinstatement of alcohol‐seeking behavior in …

CA Heidbreder, M Andreoli, C Marcon… - Addiction …, 2007 - Wiley Online Library
The present study examined the effects of the acute intraperitoneal (ip) administration of the
selective dopamine (DA) D3 receptor antagonist SB‐277011A (10, 20 or 30 mg/kg ip) on the …

Effects of raclopride in the nucleus accumbens on ethanol seeking and consumption

CL Czachowski, AM Chappell… - Alcoholism: Clinical …, 2001 - Wiley Online Library
Background: Nucleus accumbens dopamine has been shown to play a role in the
processing of behaviorally relevant stimuli and to mediate ethanol‐reinforced responding …

Alcohol self-administration: role of mesolimbic dopamine.

HH Samson, GA Tolliver, M Haraguchi… - Annals of the New York …, 1992 - europepmc.org
It appears clear that ethanol reinforcement, like that of many abused drugs, utilizes the
mesolimbic DA pathways. From the data presented on microinjection of DA agonists and …

SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats

S Rassnick, L Pulvirenti, GF Koob - Alcohol, 1993 - Elsevier
Abstract The effects of SDZ-205,152, a synthetic mixed D1/D2 dopamine receptor agonist,
was investigated in rats trained to orally self-administer ethanol (10% w/v) in a free-choice …

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

S Rassnick, L Stinus, GF Koob - Brain research, 1993 - Elsevier
Rats readily learn to self-administer ethanol using a procedure where ethanol is introduced
in the presence of a sweetener. After gradual removal of the sweetener, sufficient quantities …

Preferential involvement of D3 versus D2 dopamine receptors in the effects of dopamine receptor ligands on oral ethanol self-administration in rats

C Cohen, G Perrault, DJ Sanger - Psychopharmacology, 1998 - Springer
There is evidence that dopamine transmission is involved in reinforcement processes and
the present study investigated the relative involvement of D 3 versus D 2 dopamine …

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

S Rassnick, L Pulvirenti, GF Koob - Psychopharmacology, 1992 - Springer
The purpose of this study was to assess the role of endogenous dopamine and glutamate
systems within the nucleus accumbens in modulating responses for oral ethanol …

Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice

FO Risinger, PA Freeman, M Rubinstein, MJ Low… - …, 2000 - Springer
Rationale: Dopamine D 2 receptors are postulated to play an important role in modulating
the reinforcing effects of abused drugs including ethanol. Objectives: This experiment …