Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6ε from two Plasmodium falciparum parasite lines

S Gangnard, C Badaut, S Ramboarina, B Baron… - Journal of molecular …, 2013 - Elsevier
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a family of adhesins of
the falciparum species of the malaria parasite, is exposed on the surface of the infected …

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions

S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …

[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

Structural insights into chondroitin sulphate A binding Duffy-binding-like domains from Plasmodium falciparum: implications for intervention strategies against …

J Gill, CE Chitnis, A Sharma - Malaria Journal, 2009 - Springer
Background Placental malaria is typified by selective clustering of Plasmodium falciparum in
the intervillous blood spaces of the placenta. Sequestration of malaria parasite in the human …

Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of …

T Saveria, AV Oleinikov, K Wiliamson… - Infection and …, 2013 - Am Soc Microbiol
Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

A Srivastava, S Gangnard, A Round… - Proceedings of the …, 2010 - National Acad Sciences
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

K Singh, AG Gittis, P Nguyen, DC Gowda… - Nature structural & …, 2008 - nature.com
Plasmodium falciparum–infected erythrocytes bind to chondroitin sulfate A (CSA) in the
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …

Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay

H Obiakor, M Avril, NJ MacDonald… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
ABSTRACT VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region

K Singh, RK Gitti, A Diouf, H Zhou, DC Gowda… - Journal of Biological …, 2010 - ASBMB
Molecular interactions between the VAR2CSA protein, expressed on the surface of
Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are …

Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family

JD Smith, G Subramanian, B Gamain, DI Baruch… - Molecular and …, 2000 - Elsevier
The Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of
cytoadherent proteins has a central role in disease from malaria infection. This highly …