Mitochondrial sirtuins in chronic degenerative diseases: new metabolic targets in colorectal cancer
A Colloca, A Balestrieri, C Anastasio… - International Journal of …, 2022 - mdpi.com
Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven
members, widely expressed in mammals. SIRTs mainly participate in metabolic …
members, widely expressed in mammals. SIRTs mainly participate in metabolic …
Mitochondrial sirtuins in cancer: emerging roles and therapeutic potential
The past few decades have witnessed a furious attention of scientific community toward
identifying novel molecular factors and targets that could be exploited for drug development …
identifying novel molecular factors and targets that could be exploited for drug development …
[HTML][HTML] Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies
H Shen, W Ma, Y Hu, Y Liu, Y Song, L Fu, Z Qin - Theranostics, 2024 - ncbi.nlm.nih.gov
The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …
nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3 …
Mitochondrial sirtuins in stem cells and cancer
A Jaiswal, Z Xudong, J Zhenyu, G Saretzki - The FEBS Journal, 2022 - Wiley Online Library
The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and
SIRT5) localise specifically within mitochondria and preserve mitochondrial function and …
SIRT5) localise specifically within mitochondria and preserve mitochondrial function and …
Mitochondrial sirtuins and their relationships with metabolic disease and cancer
S Kumar, DB Lombard - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: Maintenance of metabolic homeostasis is critical for cellular and organismal
health. Proper regulation of mitochondrial functions represents a crucial element of overall …
health. Proper regulation of mitochondrial functions represents a crucial element of overall …
[HTML][HTML] Mitochondrial sirtuins: Energy dynamics and cancer metabolism
H Lee, H Yoon - Molecules and Cells, 2024 - Elsevier
Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial
sirtuins,(Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This …
sirtuins,(Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This …
Interplay between SIRT-3, metabolism and its tumor suppressor role in hepatocellular carcinoma
S De Matteis, AM Granato, R Napolitano… - Digestive diseases and …, 2017 - Springer
Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent
type III histone deacetylases, are produced by cells to support in the defense against chronic …
type III histone deacetylases, are produced by cells to support in the defense against chronic …
Mitochondrial sirtuins as therapeutic targets for age-related disorders
Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the
cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria …
cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria …
[HTML][HTML] Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway
Y Wang, X Sun, K Ji, L Du, C Xu, N He, J Wang… - Biomedicine & …, 2018 - Elsevier
Abstract Sirtuin-3 (Sirt3), a sub-family member of the nicotinamide adenine dinucleotide-
dependent histone deacetylases, has been reported to be involved in mitochondrial …
dependent histone deacetylases, has been reported to be involved in mitochondrial …
Mitochondrial sirtuins: emerging roles in metabolic regulations, energy homeostasis and diseases
P Parihar, I Solanki, ML Mansuri, MS Parihar - Experimental gerontology, 2015 - Elsevier
The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …
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