Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of …

Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of
aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Tumor hypoxia presents a unique therapeutic challenge in the treatment of solid
malignancies. Its presence has been established to be a poor prognostic factor in multiple …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …