Inherent and tumor-driven immune tolerance in the prostate microenvironment impairs natural killer cell antitumor activity
C Pasero, G Gravis, M Guerin, S Granjeaud… - Cancer research, 2016 - AACR
The field of immunotherapy for solid tumors, such as prostate cancer, has been recently
focusing on therapies that can counter tumor-mediated immunosuppression. Precise …
focusing on therapies that can counter tumor-mediated immunosuppression. Precise …
Reduction of the CD16−CD56bright NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
Background Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role
in the inhibition and elimination of malignant tumor cells. To investigate the …
in the inhibition and elimination of malignant tumor cells. To investigate the …
Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis
G Liu, S Lu, X Wang, ST Page… - The Journal of …, 2013 - Am Soc Clin Investig
The activating receptor NK cell group 2 member D (NKG2D) mediates antitumor immunity in
experimental animal models. However, whether NKG2D ligands contribute to tumor …
experimental animal models. However, whether NKG2D ligands contribute to tumor …
Impact of tumor and immunological heterogeneity on the anti-cancer immune response
Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest
in the immunologic control of malignancy has helped establish escape from …
in the immunologic control of malignancy has helped establish escape from …
Past, current, and future of immunotherapies for prostate cancer
AN Boettcher, A Usman, A Morgans… - Frontiers in …, 2019 - frontiersin.org
Prostate cancer (PCa) is the most common cancer in men, and the second leading cause of
cancer related death in men in Western countries. The standard therapy for metastatic PCa …
cancer related death in men in Western countries. The standard therapy for metastatic PCa …
Influence of the tumor microenvironment on NK cell function in solid tumors
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …
host immune responses against infection and tumor growth. These cells have a powerful …
Natural killer cell interactions with myeloid derived suppressor cells in the tumor microenvironment and implications for cancer immunotherapy
The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …
[HTML][HTML] Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions
J Russick, PE Joubert, M Gillard-Bocquet… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to build …
their cytotoxic effector functions and their capacity to interact with other immune cells to build …
Role of distinct natural killer cell subsets in anticancer response
Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …
effectors of anticancer immune response. These cells can survey and control tumor initiation …
[HTML][HTML] Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer
C Pasero, G Gravis, S Granjeaud, M Guerin… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Clinical outcome of patients with metastatic prostate cancer (mPC) at diagnosis is
heterogeneous and unpredictable; thus alternative treatments such as immunotherapy are …
heterogeneous and unpredictable; thus alternative treatments such as immunotherapy are …