Associations between hematopoietic cells and their microenvironment are central to the
development and maintenance of a functional hematopoietic system. It is important …

HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

Hematopoietic progenitor cells are incubated with cytokine combinations for in vitro
expansion of stem cells and to enhance retrovirus-mediated gene transfer. Optimization of …

Abstract Here, Martin Hemler focuses on the emerging field of hematopooetic cell adhesion
to extracellular matrix. Analysis of newly discovered receptor structures involved in cell …

Blood cells developing in the bone marrow exhibit adhesive interactions with stromal
reticular cells and specialized macrophages, and with several defined components of the …

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the
bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic …

Normal steady-state hematopoiesis takes place in the bone marrow microenvironment.
Soluble factors as well as contact interactions between the hematopoietic cells and the …

Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the
marrow microenvironment. This work characterizes the expression of various adhesive …

The mechanism of localization, migration, and regulation of hematopoiesis at different
stages of ontogeny is not well understood, but may relate to the specific adhesive …

The hematopoietic microenvironment is a complex structure in which stem cells, progenitor
cells, stromal cells, growth factors, and extracellular matrix (ECM) molecules each interact to …