Characterization of PEDF: a multi‐functional serpin family protein

S Filleur, T Nelius, W De Riese… - Journal of cellular …, 2009 - Wiley Online Library
Pigment epithelium‐derived factor (PEDF) is a 50 kDa secreted glycoprotein that belongs to
the non‐inhibitory serpin family group. PEDF has been described as a natural angiogenesis …

Structure-function relationships of PEDF

T Kawaguchi, SI Yamagishi… - Current molecular …, 2010 - ingentaconnect.com
Pigment epithelial-derived factor (PEDF) is a 50-kDa secreted glycoprotein that belongs to
the non-inhibitory serpin. It has an α/β core serine-protease inhibitor domain, 3 major β …

Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor

L Notari, V Baladron, JD Aroca-Aguilar, N Balko… - Journal of biological …, 2006 - ASBMB
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein
belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic …

How PEDF prevents angiogenesis: a hypothesized pathway

JG Ren, C Jie, C Talbot - Medical hypotheses, 2005 - Elsevier
Pigment epithelium-derived factor (PEDF) is a multiple functional protein, coded by the
serine proteinase inhibitor, clade F, member 1 (SERPINF1) gene, which has both anti …

Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor

M Simonovic, PGW Gettins… - Proceedings of the …, 2001 - National Acad Sciences
Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serpin superfamily,
is the most potent inhibitor of angiogenesis in the mammalian ocular compartment. It also …

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization

SV Petersen, Z Valnickova, JJ Enghild - Biochemical Journal, 2003 - portlandpress.com
Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye
by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or …

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases

X He, R Cheng, S Benyajati, J Ma - Clinical science, 2015 - portlandpress.com
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of
the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles …

Pigment epithelium-derived factor: a multimodal tumor inhibitor

ETH Ek, CR Dass, PFM Choong - Molecular cancer therapeutics, 2006 - AACR
Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease
inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has …

Role of pigment epithelium‐derived factor in stem/progenitor cell‐associated neovascularization

JT Liu, YL Chen, WC Chen, HY Chen… - BioMed Research …, 2012 - Wiley Online Library
Pigment epithelium‐derived factor (PEDF) was first identified in retinal pigment epithelium
cells. It is an endogenously produced protein that is widely expressed throughout the human …

The role of PEDF in tumor growth and metastasis

D Hoshina, R Abe, SI Yamagishi… - Current molecular …, 2010 - ingentaconnect.com
Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely
expressed throughout the body. Although PEDF was initially identified as a neuronal …