Adenosine has a potent depressant action on cerebral cortical neurons, including identified
corticospinal cells. Adenosine 2′-, 3′-and 5′-phosphates, including adenosine 5 …

Adenosine and the adenosine 5'-phosphates (5'-AMP, 5'-ADP and 5'-ATP) depress the
spontaneous firing of cerebral cortical neurons. In this study adenosine analogs, adenosine …

Adenosine and its analogs depress the firing of neurons in various brain regions. The
primary mode of action of adenosine in exerting this action appears to be the depression of …

Reviews recent research on the role of endogenous adenosine in brain function and
behavior. The presence, distribution, biosynthesis, release, uptake, catabolism, actions, and …

Brain adenosine receptors, like those in other tissues (Williams, 1989), can be delineated
into two major subclasses, termed A 1 and A 2 (Hamprecht and Van Calker, 1985), and …

About ten years ago, Ginsborg and Hirst [1] found that adenosine reduced the quantum
content and the frequency of miniature end-plate potentials in the rat phrenic nerve …

Adenosine is able to decrease the release of most neurotransmitters. This is consistent with
its general role in adjusting the rate of energy consumption to the metabolic supply in a …

Adenosine and the methylxanthines have marked and opposite effects on behavior both of
which are now thought to be mediated by cell surface adenosine receptors present in brain …

Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with
the adenosine A 1 receptor. There is now also evidence for electrophysiological effects …

▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …