Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect
with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P …

Majoradvances in the diagnosis and treatment of oral clefts have been made in the past 50
years, and recent genetics and epidemiological studies have led to new theories about the …

Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …

Nonsyndromic cleft lip and palate is a complex genetic disorder with variable phenotype,
largely attributed to the interactions of the environment and multiple genes, each potentially …

BACKGROUND Understanding the etiology of birth defects is an important step toward
developing improved treatment and preventive strategies. Most birth defects have an …

Nonsyndromic or isolated cleft lip with or without cleft palate (CL/P) occurs in wide
geographic distribution with an average birth prevalence of 1/700. We used direct …

Objective The members of the International Consortium for Oral Clefts Genetics recognize
the need for collaboration between researchers involved in etiologic studies of …

Cleft of the lip with or without cleft palate (CL/P) represents one of the commonest congenital
malformations in Western countries. Based on their association with specific malformative …

Background Oral clefts, that is, clefts of the lip and/or cleft palate (CL/P), are the most
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …

Objective. To review recent data on the aetiology of cleft lip and palate. Data sources.
MEDLINE literature search (1986-2003). Study selection. Literature and data on aetiology of …