Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models
HS Baek, VS Hong, H Kang, SJ Lee, JY Lee… - Inflammation …, 2024 - Springer
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder characterized by joint
destruction due to synovial hypertrophy and the infiltration of inflammatory cells. Despite …
destruction due to synovial hypertrophy and the infiltration of inflammatory cells. Despite …
KMU-1170, a novel multi-protein kinase inhibitor, suppresses inflammatory signal transduction in THP-1 cells and human osteoarthritic fibroblast-like synoviocytes by …
HS Baek, VS Hong, SH Kim, J Lee, S Kim - International Journal of …, 2021 - mdpi.com
Protein kinases regulate protein phosphorylation, which are involved in fundamental cellular
processes such as inflammatory response. In this study, we discovered a novel multi-protein …
processes such as inflammatory response. In this study, we discovered a novel multi-protein …
Novel Leflunomide Analog, UTLOH-4e, Ameliorates Gouty Arthritis Induced by Monosodium Urate Via NF-ΚB/NLRP3 Signaling Pathway
T Yuan, S Chen, Y Yin, J Shaw, J Zeng… - Current …, 2024 - ingentaconnect.com
Background: Gouty arthritis (GA) is a common form of inflammatory arthritis caused by intra-
articular deposition of monosodium urate (MSU) crystals; however, there is a tremendous …
articular deposition of monosodium urate (MSU) crystals; however, there is a tremendous …
FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways
N Zhang, Z Liu, H Luo, W Wu, K Nie, L Cai… - Bioscience …, 2019 - portlandpress.com
Background: Rheumatoid arthritis (RA) is a chronic articular synovial inflammatory disease.
The precise etiology underlying the pathogenesis of RA remains unknown. We aimed to …
The precise etiology underlying the pathogenesis of RA remains unknown. We aimed to …
Op0133 preclinical efficacy of r835, a novel irak1/4 dual inhibitor, in rodent models of joint inflammation
C Lamagna, M Chan, E Tai, S Siu, R Frances, S Yi… - 2020 - ard.bmj.com
Background: Interleukin receptor associated kinases (IRAK) 1 and 4 are kinases involved in
Toll-Like Receptor (TLR) and Interleukin-1 Receptor (IL-1R) signaling pathways, which …
Toll-Like Receptor (TLR) and Interleukin-1 Receptor (IL-1R) signaling pathways, which …
TAK-242 (Resatorvid) inhibits proinflammatory cytokine production through the inhibition of NF-κB signaling pathway in fibroblast-like synoviocytes in osteoarthritis …
Abstract Background Fibroblast-like synoviocytes (FLSs) are involved in osteoarthritis (OA)
pathogenesis through pro-inflammatory cytokine production. TAK-242, a TLR4 blocker, has …
pathogenesis through pro-inflammatory cytokine production. TAK-242, a TLR4 blocker, has …
Potent anti‐inflammatory effects of the narrow spectrum kinase inhibitor RV 1088 on rheumatoid arthritis synovial membrane cells
WS To, SR Aungier, AJ Cartwright, K Ito… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose To investigate whether a narrow spectrum kinase inhibitor RV
1088, which simultaneously targets specific MAPKs, S rc and spleen tyrosine kinase (Syk), is …
1088, which simultaneously targets specific MAPKs, S rc and spleen tyrosine kinase (Syk), is …
(E)-3-(3, 4-Dimethoxyphenyl)-1-(5-hydroxy-2, 2-dimethyl-2H-chromen-6-yl) prop-2-en-1-one ameliorates the collagen-arthritis via blocking ERK/JNK and NF-κB …
X Li, F Peng, C Xie, W Wu, X Han, L Chen - International …, 2013 - Elsevier
Our previous report has shown a natural pyranochalcones-derived compound,(E)-3-(3, 4-
Dimethoxyphenyl)-1-(5-hydroxy-2, 2-dimethyl-2H-chromen-6-yl) prop-2-en-1-one (5b), that …
Dimethoxyphenyl)-1-(5-hydroxy-2, 2-dimethyl-2H-chromen-6-yl) prop-2-en-1-one (5b), that …
Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-κB) pathway
C Shu, J Chen, M Lv, Y Xi, J Zheng, X Xu - Bioengineered, 2022 - Taylor & Francis
This study aimed to explore the effects of plumbagin on rheumatoid arthritis (RA) and its
mechanism. The RA cell model was simulated following the treatment of interleukin-1β (IL …
mechanism. The RA cell model was simulated following the treatment of interleukin-1β (IL …
SKLB023 blocks joint inflammation and cartilage destruction in arthritis models via suppression of nuclear factor-kappa B activation in macrophage
C Xie, L Ma, J Liu, X Li, H Pei, M Xiang, L Chen - PloS one, 2013 - journals.plos.org
Rheumatoid arthritis (RA) is the most common arthritis and is mainly characterized by
symmetric polyarticular joint disorders. Our previous study demonstrated a novel small …
symmetric polyarticular joint disorders. Our previous study demonstrated a novel small …
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