Background—The progression of atrial fibrillation (AF) from paroxysmal to persistent forms
remains a major clinical challenge. Abnormal sarcoplasmic reticulum (SR) Ca2+ leak via the …

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …

Although atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, the
basic mechanisms underlying this disorder remain incompletely understood. During the past …

Background—Ca2+ leak from the sarcoplasmic reticulum (SR) may play an important role in
triggering and/or maintaining atrial arrhythmias, including atrial fibrillation (AF). Protein …

Abstract Aims Altered Ca2+ handling in atrial fibrillation (AF) has been associated with
dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein …

Background: Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …

Rationale: Atrial fibrillation (AF) is the most common cardiac arrhythmia, however the
mechanism (s) causing AF remain poorly understood and therapy is suboptimal. The …

During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …

Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …