Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

The interplay among reactive oxygen species (ROS) formation, elevated intracellular
calcium concentration and mitochondrial demise is a recurring theme in research focusing …

Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites within
the organelle. The balance in their formation and elimination is maintained by a complex …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

The versatility of mitochondrial metabolism and its fine adjustments to specific physiological
or pathological conditions regulate fundamental cell pathways, ranging from proliferation to …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

Mitochondria are central to energy metabolism as the source of much of the cell's ATP, as
well as being a hub for cellular Ca 2+ signaling. Mitochondrial Ca 2+ is a positive effector of …

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

A number of recent discoveries indicate that abnormal Ca 2+ signaling, oxidative stress, and
mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease …