Hypoxia-inducible factors (HIFs) are master regulators of adaptive responses to low oxygen,
and their α-subunits are rapidly degraded through the ubiquitination-dependent …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a master transcriptional regulator of cellular
response to hypoxia. In normoxia, HIF-1α is degraded through the prolyl hydroxylase (PHD) …

Oxygen homeostasis is crucial for a myriad of developmental, physiological, and
pathophysiological processes. Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in …

The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …

Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia.
HIF is a heterodimeric transcription factor consisting of an oxygen-regulated alpha-and a …

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible
factors (HIF s), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β …

Hypoxia inevitably develops in rapidly growing tumors and acts as an important
microenvironment that forces changes in tumor behavior. Hypoxia-inducible factor 1α (HIF …

Abstract Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen
homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in …

Most solid tumors and their metastases experience periods of low oxygen or hypoxia, which
is of major clinical significance as it promotes both tumor progression and resistance to …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …