Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer
cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular …

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

Tumour hypoxia promotes the accumulation of the otherwise oxygen‐labile hypoxia‐
inducible factor (HIF)‐α subunit whose expression is associated with cancer progression …

The hypoxia-inducible factor (HIF-1α) functions as a master regulator of oxygen
homeostasis. Oxygen-dependent hydroxylation of HIF-1α is tightly regulated by prolyl …

The basic molecular mechanism underlying mammalian oxygen-dependent regulation of
hypoxia-inducible factor (HIF) via the von Hippel-Lindau E3 ubiquitin ligase is well …

Oxygen‐dependent proteolytic destruction of hypoxia‐inducible factor‐α (HIF‐α) subunits
plays a central role in regulating transcriptional responses to hypoxia. Recent studies have …

As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-
inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs …

Hypoxia‐inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis
elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability …