Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

The hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are dioxygenases using
oxygen and 2-oxoglutarate as co-substrates. Under normoxia, PHDs hydroxylate the …

The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐
understood oxygen‐dependent expression, regulation of its transcriptional activity remains …

Hypoxia plays a major role in the induction of angiogenesis during tumor development. One
mechanism by which tumor cells respond to a reduced oxygen level is via the activation of …

Hypoxia acts as an important regulator of physiological and pathological processes.
Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to …

HIF1 (hypoxia-inducible factor 1 alpha) is considered a central oxygen-threshold sensor in
mammalian cells. In the presence of oxygen, HIF1 is marked by prolyl hydroxylases (PHDs) …

The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon
the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to …

At the cellular level hypoxia induces transcriptional response that is mediated by the
transcription factor hypoxia-inducible factor (HIF). HIF is regulated at the level of its α subunit …

The stabilisation of HIF-α is central to the transcriptional response of animals to hypoxia,
regulating the expression of hundreds of genes including those involved in angiogenesis …

Eukaryotic cells sense oxygen and adapt to hypoxia by regulating a number of genes.
Hypoxia‐inducible factor 1 (HIF‐1) is the 'master'in this pleiotypic response. HIF‐1 …