Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia.
Under normoxic conditions, site-specific proline hydroxylation of the α subunits of HIF allows …

Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor
VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However …

As a transcription factor family dependent of oxygen, hypoxia-inducible factors (HIFs) play
important roles in organic and cellular homeostasis, which are master regulators of …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the
cellular adaptive response to hypoxia, a common feature of the microenvironment in solid …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

The cellular response to hypoxia is, at least in part, mediated by the transcriptional
regulation of hypoxia-responsive genes involved in balancing the intracellular ATP …

Over the past decade major advances have been made in our understanding of the
molecular machinery that mammalian cells use to sense and to adapt to a low-oxygen …

The major adaptive response to hypoxia involves hypoxia-inducible factor HIF-1α which is
regulated by von Hippel Lindau (VHL) E3 ligase. We previously observed a stabilization of …

Intratumoural hypoxia induces HIF-1α and promotes tumour progression, metastasis and
treatment resistance. HIF-1α stability is regulated by VHL-E3 ligase-mediated ubiquitin …

Mechanisms regulating protein degradation ensure the correct and timely expression of
transcription factors such as hypoxia inducible factor (HIF). Under normal O2 tension, HIFα …