Sepsis, acute lung injury, and ARDS contribute substantially to the expanding burden of
critical illness within our ICUs. Each of these processes is characterized by a myriad of …

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Platelets display a number of properties besides the crucial function of repairing damaged
vascular endothelium and stopping bleeding; these are exploited to benefit patients …

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

Platelets are essential cellular effectors of hemostasis and contribute to disease as
circulating effectors of pathologic thrombosis. These are their most widely known biologic …

Sepsis is defined as the systemic response to infection and is associated with a significant
mortality rate. The role of platelets in sepsis remains incompletely understood (Fig. 1). Under …

Platelets are the chief effector cells in hemostasis and have additional major functions in
inflammation, vascular integrity, and tissue repair. Platelets and the lungs have interrelated …

Despite their humble origins as anuclear fragments of megakaryocytes, platelets have
emerged as versatile mediators of thrombosis and immunity. The diverse spectrum of …

Conclusions Platelets play a complex role in sepsis; they are able to modulate not only their
own function but also that of cells around them. Further study is needed to better define the …