Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm,
are the largest protein structures of the nuclear envelope. In addition to their role in …

In addition to their established roles in nucleocytoplasmic transport, the intimate association
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …

Eukaryotic cell function depends on the physical separation of nucleoplasmic and
cytoplasmic components by the nuclear envelope (NE). Molecular communication between …

Nuclear‐pore complexes (NPCs) are large protein channels that span the nuclear envelope
(NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of …

In eukaryotic cells, the genetic material is segregated inside the nucleus. This
compartmentalization of the genome requires a transport system that allows cells to move …

The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that
mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal …

As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate
all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …