Alzheimer's disease (AD) and traumatic brain injury (TBI) are major public health issues
worldwide, with over 38 million people living with AD and approximately 48 million people …

Background: Due to their relative ease of isolation and their high ex vivo and in vitro
expansive potential, human mesenchymal stem cells (hMSCs) are an attractive candidate …

Unspecialized, self-renewing stem cells have extraordinary application to regenerative
medicine due to their multilineage differentiation potential. Stem cell therapies through …

Multipotent neural stem cells (NSCs) provide a model to investigate neurogenesis and
develop mechanisms of cell transplantation. In order to define improved markers of …

Along with the tri-lineage of bone, cartilage and fat, human mesenchymal stem cells
(hMSCs) retain neural lineage potential. Multiple factors have been described that influence …

Generating neurons from human stem cells has potential for brain damage therapy and
neurogenesis modeling, but current efficacy is limited by culture heterogeneity and the lack …

Abstract Background Neural precursor cells (NPCs) are defined by their ability to proliferate,
self-renew, and retain the potential to differentiate into neurons and glia. Deciphering the …

Astrocytes modulate many aspects of neuronal function, including synapse formation and
the response to injury. Heparan sulfate proteoglycans (HSPGs) mediate some of the effects …

Accumulation of amyloid-β (Aβ) peptide in the brain is the first critical step in the
pathogenesis of Alzheimer's disease (AD). Studies in humans suggest that Aβ clearance …

Although the local environment is known to regulate neural stem cell (NSC) maintenance in
the central nervous system, little is known about the molecular identity of the signals …