Introduction: Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose
is especially common. Serum biomarkers used to follow patient progress reflect either liver …

Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …

Introduction: Although the hepatotoxicity of acetaminophen is a well-known problem, the
search for reliable biomarker of toxicity is still a current issue as clinical tools are missing to …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …

Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs
worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing …