Advanced age is associated with alterations in innate and adaptive immune responses,
which contribute to an increased risk of infection in elderly patients. Coupled with this …

Elderly humans show increased susceptibility to invasive staphylococcal disease after skin
and soft tissue infection. However, it is not understood how host immunity changes with …

We have previously shown that healthy older adults exhibit reduced cutaneous immune
responses during a varicella zoster virus (VZV) antigen challenge that correlated with a …

Previous studies have documented that the ability to heal wounds declines with age.
Although many factors contribute to this age-associated deficit, one variable that has not …

Aging is associated with dysregulated immune functions. Here, we investigated the impact of
age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged …

Elderly humans are more susceptible to bacterial infections because of declining immune
status. We have investigated the effect of aging on neutrophil bactericidal responses …

The impact of ageing in innate immunity is poorly understood. Studies in the mouse model
have described altered innate immune functions in aged macrophages, although these were …

Ageing is a universal biological phenomenon that is accompanied by the development of
chronic, low-grade inflammation and remodelling of the immune system resulting in …

One of the most important clinical problems in caring for elderly patients is treatment of
pressure ulcers. One component of normal wound healing is the generation of an …

Delayed and often impaired wound healing in the elderly presents major medical and
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …