[PDF][PDF] Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II
MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …
Structural basis for HLA–DQ binding by the streptococcal superantigen SSA
E Sundberg, TS Jardetzky - nature structural biology, 1999 - nature.com
Streptococcal superantigen (SSA) is a 28,000 M r toxin originally isolated from a pathogenic
strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal …
strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal …
[HTML][HTML] Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence
K Petersson, M Håkansson, H Nilsson… - The EMBO …, 2001 - embopress.org
The three‐dimensional structure of a bacterial superantigen, Staphylococcus aureus
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …
[HTML][HTML] Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule
MM Fernández, R Guan, CP Swaminathan… - Journal of biological …, 2006 - ASBMB
Superantigens are bacterial or viral proteins that elicit massive T cell activation through
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …
Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus …
Bacterial superantigens (SAgs) are a structurally related group of protein toxins secreted by
Staphylococcus aureus and Streptococcus pyogenes. They are implicated in a range of …
Staphylococcus aureus and Streptococcus pyogenes. They are implicated in a range of …
Major histocompatibility complex class II‐associated peptides determine the binding of the superantigen toxic shock syndrome toxin‐1
A von Bonin, S Ehrlich, G Malcherek… - European journal of …, 1995 - Wiley Online Library
Superantigens bind to major histocompatibility complex (MHC) class II proteins and interact
with variable parts of the T cell antigen receptor (TCR) β‐chain. Cross‐linking the TCR with …
with variable parts of the T cell antigen receptor (TCR) β‐chain. Cross‐linking the TCR with …
The structural basis of T cell activation by superantigens
▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …
Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM
PM Lavoie, J Thibodeau, I Cloutier… - Proceedings of the …, 1997 - National Acad Sciences
Bacterial superantigens (SAgs) bind to major histocompatibility complex (MHC) class II
molecules and activate T cells in a Vβ-restricted fashion. We recently identified subsets of …
molecules and activate T cells in a Vβ-restricted fashion. We recently identified subsets of …
Crystal structure of a T-cell receptor β-chain complexed with a superantigen
SUPERANTIGENS (SAgs) are viral or bacterial proteins that act as potent T-cell stimulants
and have been implicated in a number of human diseases, including toxic shock …
and have been implicated in a number of human diseases, including toxic shock …