Abstract'Superantigens'(SAgs) trigger the massive activation of T cells by simultaneous
interactions with MHC and TCR receptors, leading to human diseases. Here we present the …

Major histocompatibility complex (MHC) class II molecules display peptides to the T cell
receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented …

Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T‐
cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines …

Superantigen binding to MHC class II molecules is a prerequisite for T cell stimulation. While
the presentation of superantigens is not MHC restricted, allelic and isotypic variations in the …

The three-dimensional structure of an unglycosylated T cell antigen receptor (TCR) beta
chain has recently been determined to 1.7 A resolution. To investigate whether this soluble …

Superantigens are a class of highly potent immuno-stimulatory molecules produced by
Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique …

Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a
pathophysiological role in Gram‐positive septic shock and food poisoning. To characterize …

Superantigens bind to major histocompatibility complex class II molecules on antigen-
presenting cells and stimulate T cells. Staphylococcus aureus enterotoxin B (SEB) and toxic …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

Superantigens are highly potent immune stimulators with a unique ability to interact
simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular …