The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response …

C Baraquet, K Murakami, MR Parsek… - Nucleic acids …, 2012 - academic.oup.com
Abstract Bis-(3′–5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) modulates the
transition between planktonic and biofilm life styles. In response to c-di-GMP, the enhancer …

C‐di‐GMP regulates the expression of lapA and bcs operons via FleQ in Pseudomonas putida KT2440

Y Xiao, H Nie, H Liu, X Luo, W Chen… - Environmental …, 2016 - Wiley Online Library
Cyclic diguanylate (c‐di‐GMP) positively modulates the production of biofilm matrix
components from the transcriptional to the post‐translational level in a variety of bacterial …

Genome-wide analysis of the FleQ direct regulon in Pseudomonas fluorescens F113 and Pseudomonas putida KT2440

E Blanco-Romero, M Redondo-Nieto… - Scientific reports, 2018 - nature.com
Bacterial motility plays a crucial role in competitiveness and colonization in the rhizosphere.
In this work, Chromatin ImmunoPrecipitation Sequencing (ChIP-seq) analysis has been …

Interaction of the Antiactivator FleN with the Transcriptional Activator FleQ Regulates Flagellar Number inPseudomonas aeruginosa

N Dasgupta, R Ramphal - Journal of bacteriology, 2001 - Am Soc Microbiol
Flagellar number in Pseudomonas aeruginosa is controlled by FleN, a putative ATP/GTP
binding protein. Disruption of fleN results in multiflagellation of the otherwise monoflagellate …

Multiple Copies of flhDC in Paraburkholderia unamae Regulate Flagellar Gene Expression, Motility, and Biofilm Formation

SNM Thai, MR Lum, J Naegle, M Onofre… - Journal of …, 2021 - Am Soc Microbiol
FlhDC is a heterohexameric complex that acts as a master regulator of flagellar biosynthesis
genes in numerous bacteria. Previous studies have identified a single flhDC operon …

A Conservative Amino Acid Mutation in the Master Regulator FleQ Renders Pseudomonas aeruginosa Aflagellate

R Jain, BI Kazmierczak - PLoS One, 2014 - journals.plos.org
Flagellar-based motility plays a critical role in Pseudomonas aeruginosa pathogenesis,
influencing both the establishment of bacterial infection and the host's response to the …

The Pseudomonas aeruginosa Flagellar Cap Protein, FliD, Is Responsible for Mucin Adhesion

SK Arora, BW Ritchings, EC Almira, S Lory… - Infection and …, 1998 - Am Soc Microbiol
Mucin-specific adhesion of Pseudomonas aeruginosa plays an important role in the initial
colonization of this organism in the airways of cystic fibrosis patients. We report here that the …

Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control

L Torres-Sánchez, TG Sana… - Proceedings of the …, 2023 - National Acad Sciences
Pseudomonas aeruginosa can cause a wide array of chronic and acute infections
associated with its ability to rapidly switch between planktonic, biofilm, and dispersed …

A Two-Component System FleS/FleR Regulates Multiple Virulence-Related Traits in Pseudomonas aeruginosa

T Zhou, J Huang, Q Feng, Z Liu, Q Lin, Z Xu, LH Zhang - BioRxiv, 2021 - biorxiv.org
Microorganisms commonly use two-component systems (TCSs) to detect specific
environmental changes and respond accordingly for their own benefit. However, the …

Identification of c-di-GMP/FleQ-Regulated New Target Genes, Including cyaA, Encoding Adenylate Cyclase, in Pseudomonas putida

Y Xiao, H Chen, L Nie, M He, Q Peng, W Zhu, H Nie… - Msystems, 2021 - Am Soc Microbiol
The bacterial second messenger cyclic diguanylate (c-di-GMP) modulates plankton-to-
biofilm lifestyle transition of Pseudomonas species through its transcriptional regulatory …