Global regulatory pathways converge to control expression of Pseudomonas aeruginosa Type IV Pili

KA Coggan, MG Higgs, ED Brutinel, JN Marden… - Mbio, 2022 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa relies upon type IV pili (Tfp) for host
colonization and virulence. Tfp are retractile surface appendages that promote adherence to …

[HTML][HTML] Effect of the Flagellar Gene fliL on the Virulence of Pseudomonas plecoglossicida to Hybrid Grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂)

L Shi, J Zhang, L Zhao, Q Li, L Huang, Y Qin, Q Yan - Fishes, 2023 - mdpi.com
Pseudomonas plecoglossicida is the pathogen of visceral white spot disease in marine fish,
which usually occurs at 16–19° C and has resulted in heavy economic losses. Our previous …

Role of the biofilm master regulator CsgD in cross-regulation between biofilm formation and flagellar synthesis

H Ogasawara, K Yamamoto, A Ishihama - Journal of bacteriology, 2011 - Am Soc Microbiol
CsgD, the master regulator of biofilm formation, activates the synthesis of curli fimbriae and
extracellular polysaccharides in Escherichia coli. To obtain insights into its regulatory role …

Regulation of flagellum number by FliA and FlgM and role in biofilm formation by Rhodobacter sphaeroides

DA Wilkinson, SJ Chacko, C Vénien-Bryan… - Journal of …, 2011 - Am Soc Microbiol
The FlgM secretion checkpoint plays a crucial role in coordinating bacterial flagellar
assembly. Here we identify a new role for FlgM and FliA as part of a complex regulatory …

[HTML][HTML] Flagellar Hook Protein FlgE Induces Microvascular Hyperpermeability via Ectopic ATP Synthase β on Endothelial Surface

Y Li, Y Shen, Y Zheng, S Ji, M Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
We previously demonstrated the immunostimulatory efficacy of Pseudomonas aeruginosa
flagellar hook protein FlgE on epithelial cells, presumably via ectopic ATP synthases or …

[HTML][HTML] The platform protein is essential for type IV pilus biogenesis

HK Takhar, K Kemp, M Kim, PL Howell… - Journal of Biological …, 2013 - ASBMB
A systematic genetic analysis was performed to identify the inner membrane proteins
essential for type IV pilus (T4P) expression in Pseudomonas aeruginosa. By inactivating the …

Hha controls Escherichia coli O157: H7 biofilm formation by differential regulation of global transcriptional regulators FlhDC and CsgD

VK Sharma, BL Bearson - Applied and environmental …, 2013 - Am Soc Microbiol
Although molecular mechanisms promoting adherence of enterohemorrhagic Escherichia
coli (EHEC) O157: H7 on epithelial cells are well characterized, regulatory mechanisms …

Extensive alanine scanning reveals protein–protein and protein–DNA interaction surfaces in the global regulator FlhD from Escherichia coli

A Campos, P Matsumura - Molecular Microbiology, 2001 - Wiley Online Library
FlhD and FlhC are the transcriptional activators of the flagellar regulon. The heterotetrameric
complex formed by these two proteins activates the transcription of the class II flagellar …

[HTML][HTML] Modulation of flagellar rotation in surface-attached bacteria: a pathway for rapid surface-sensing after flagellar attachment

M Schniederberend, JF Williams, E Shine… - PLoS …, 2019 - journals.plos.org
Attachment is a necessary first step in bacterial commitment to surface-associated behaviors
that include colonization, biofilm formation, and host-directed virulence. The Gram-negative …

[HTML][HTML] Characterization of a Novel Regulator of Biofilm Formation in the Pathogen Legionella pneumophila

C Marin, OK Kumova, S Ninio - Biomolecules, 2022 - mdpi.com
Legionella pneumophila is a Gram-negative, facultative intracellular pathogen that causes
severe pneumonia known as Legionnaires' disease. The bacterium causes disease when …