[PDF][PDF] In silico docking studies of cholesterol esterase inhibitory activity of commercially available flavonoids
S Muthukrishnan - Int J Pharm Educ Res, 2014 - researchgate.net
The main objective of the current study is to investigate the cholesterol esterase inhibitory
activity of flavonoids using in silico docking studies. In this standpoint, flavonoids like …
activity of flavonoids using in silico docking studies. In this standpoint, flavonoids like …
Computational simulation of the effect of quantum chemical parameters on the molecular docking of HMG-CoA reductase drugs
Density functional theory (B3LYP-6-31G (d)) was performed to study the effect of molecular
and electronic structures, of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones as …
and electronic structures, of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones as …
Reliable structural information for rational design of benzoxazole type potential cholesteryl ester transfer protein (CETP) inhibitors through multiple validated modeling …
The drug design and discovery of lipid modulators is very demanding as no new molecule
has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is …
has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for esterase inhibitors
Background: Esterase is an enzyme that splits esters into an acid and alcohol. Varieties of
esterases are present in human body to control diverse set of cellular processes and …
esterases are present in human body to control diverse set of cellular processes and …
Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations
Z Wang, L Cheng, Z Kai, F Wu, Z Liu, M Cai - Bioorganic & Medicinal …, 2014 - Elsevier
Hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) is generally regarded as targets
for the treatment of hypercholesterolemia. HMGR inhibitors (more commonly known as …
for the treatment of hypercholesterolemia. HMGR inhibitors (more commonly known as …
Design and development of novel therapeutics for coronary heart disease treatment based on cholesteryl ester transfer protein inhibition – in silico approach
T Kostić, M Deljanin Ilić, Z Perišić, D Milić… - Journal of …, 2020 - Taylor & Francis
Cholesteryl ester transfer protein (CETP) belongs to the group of enzymes which inhibition
have the application in the treatment of cardiovascular diseases. This study presents QSAR …
have the application in the treatment of cardiovascular diseases. This study presents QSAR …
[PDF][PDF] Cholesterol esterase inhibitory activity of flavonoids using in silico and in vitro studies
T Sivashanmugam, S Muthukrishnan… - Asian Pacific J …, 2013 - researchgate.net
Objective: To investigate the cholesterol esterase inhibitory activity of flavonoids using in
silico and in vitro studies. Methods: In this perspective, flavonoids like catechin, chalcone, 4 …
silico and in vitro studies. Methods: In this perspective, flavonoids like catechin, chalcone, 4 …
Artificial neural network‐based quantitative structure–activity relationships model and molecular docking for virtual screening of novel potent acetylcholinesterase …
The deficit in cholinergic neurotransmission is the main incentives for the development of
new therapeutic drugs for the treatment of Alzheimer's disease (AD). In this study, we …
new therapeutic drugs for the treatment of Alzheimer's disease (AD). In this study, we …
Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations
SS Song, CP Sun, JJ Zhou, L Chu - International journal of biological …, 2019 - Elsevier
In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …
Comprehensive computational study in the identification of novel potential cholesterol lowering agents targeting proprotein convertase subtilisin/kexin type 9
D Maliwal, RRS Pissurlenkar… - Journal of Biomolecular …, 2024 - Taylor & Francis
The enzymatic target proprotein convertase subtilisin/kexin type 9 (PCSK9) is critically
involved in the regulation of the lipoprotein metabolism leading to the degradation of low …
involved in the regulation of the lipoprotein metabolism leading to the degradation of low …