Human tetraspanin CD81 is a putative receptor for hepatitis C virus (HCV), because it has
been shown to bind 'bona fide'HCV particles. CD81, as all tetraspanins, spans the …

The CD81 tetraspanin was first identified as a hepatitis C virus (HCV) receptor by its ability to
bind the soluble ectodomain of envelope glycoprotein E2 (sE2). More recently, it has been …

Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of
which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop …

Hepatitis C virus (HCV) causes chronic liver disease, cirrhosis, and primary liver cancer.
Despite 130 million people being at risk worldwide, no vaccine exists, and effective therapy …

The tetraspanin CD81 plays an essential role in diverse cellular processes. CD81 also acts
as an entry receptor for HCV through an interaction between the large extracellular loop …

As the human tetraspanin CD81 binds hepatitis C virus (HCV) envelope glycoprotein E2, we
addressed the role CD81 may play in cellular trafficking of HCV envelope proteins. Studies …

Human CD81, a known receptor for hepatitis C virus envelope E2 glycoprotein, is a
transmembrane protein belonging to the tetraspanin family. The crystal structure of human …

The study of membrane protein structure and function requires their high-level expression
and purification in fully functional form. We previously used a tetracycline-inducible stable …

CD81, a member of the tetraspanin integral membrane protein family, has been identified as
an essential receptor for HCV (hepatitis C virus). The present review highlights recent …

ABSTRACT A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds
specifically to the surface of cells expressing human CD81 (hCD81) but not other members …