We used BIAcore to analyze the kinetics of interactions between CD81 and hepatitis C virus
(HCV) envelope proteins. We immobilized different forms of HCV envelope proteins (E1E2 …

ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV);
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …

In the past several years, a number of cellular proteins have been identified as candidate
entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection …

Hepatitis C virus (HCV) or HCV–low-density lipoprotein (LDL) complexes interact with the
LDL receptor (LDLr) and the HCV envelope glycoprotein E2 interacts with CD81 in vitro …

Tetraspanins are integral transmembrane proteins organized in microdomains displaying
specific and direct interactions with other tetraspanins and molecular partners. Among them …

Hepatitis C virus-positive serum (HCVser, genotypes 1a to 3a) or HCV cell culture
(JFH1/HCVcc) infection of primary normal human hepatocytes was assessed by measuring …

Several cell surface molecules have been proposed as receptor candidates, mediating cell
entry of hepatitis C virus (HCV) on the basis of their physical association with virions or with …

The hepatitis C virus (HCV) is a causal agent of chronic liver infection, cirrhosis, and
hepatocellular carcinoma infecting more than 170 million people. CD81 is a receptor for …

The large extracellular domain of CD81, a member of the tetraspanin family and a receptor
protein for hepatitis C virus envelope E2 glycoprotein, has been expressed, purified and …

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope
glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 …