CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

S Mii, A Enomoto, Y Shiraki, T Taki… - Pathology …, 2019 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein and a member of the α2‐
macroglobulin/C3, C4, C5 family of thioester‐containing proteins first identified as being …

High‐level expression of CD109 is frequently detected in lung squamous cell carcinomas

T Sato, Y Murakumo, S Hagiwara, M Jijiwa… - Pathology …, 2007 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol (GPI)‐anchored cell surface protein, which is a
member of the α2‐macroglobulin/C3, C4, C5 family of thioester‐containing proteins. It has …

[HTML][HTML] Epidermal hyperplasia and appendage abnormalities in mice lacking CD109

S Mii, Y Murakumo, N Asai, M Jijiwa, S Hagiwara… - The American journal of …, 2012 - Elsevier
CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is highly expressed in
several types of human cancer tissues, in particular, squamous cell carcinomas. In normal …

CD109 and squamous cell carcinoma

R Qi, F Dong, Q Liu, Y Murakumo, J Liu - Journal of Translational …, 2018 - Springer
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …

[HTML][HTML] Suppression of skin tumorigenesis in CD109-deficient mice

M Sunagawa, S Mii, A Enomoto, T Kato, Y Murakumo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed in
several types of human cancers, particularly squamous cell carcinomas. We previously …

CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro

S Zhou, SD da Silva, PM Siegel, A Philip - Scientific Reports, 2019 - nature.com
There is increasing evidence that the expression of CD109, a GPI-anchored cell surface
protein is dysregulated in squamous cell carcinoma (SCC). However, the functional role of …

[HTML][HTML] CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells

JM Zhang, Y Murakumo, S Hagiwara, P Jiang… - Biochemical and …, 2015 - Elsevier
CD109 is a glycosylphosphatidylinositol-anchored cell surface protein that is frequently
detected in squamous cell carcinomas. CD109 is a negative regulator of TGF-β1 signaling in …

Up‐regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity

S Hagiwara, Y Murakumo, T Sato, T Shigetomi… - Cancer …, 2008 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol (GPI)–anchored glycoprotein whose expression is
up‐regulated in squamous cell carcinomas (SCCs) of the lung, esophagus, and uterus. The …

CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells

S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …

Cell surface antigen CD109 is a novel member of the α2 macroglobulin/C3, C4, C5 family of thioester-containing proteins

M Lin, DR Sutherland, W Horsfall… - Blood, The Journal …, 2002 - ashpublications.org
Cell surface antigen CD109 is a glycosylphosphatidylinositol (GPI)–linked glycoprotein of
approximately 170 kd found on a subset of hematopoietic stem and progenitor cells and on …