Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond

M Ölander, BS Sixt - PLoS Pathogens, 2022 - journals.plos.org
As their designation implies, obligate intracellular bacteria are microbes that have
developed lifestyles so closely entwined with the cells of the hosts they infect that they can …

The obligate intracellular lifestyle

KA Fields, RA Heinzen, R Carabeo - Frontiers in microbiology, 2011 - frontiersin.org
Obligate intracellular bacteria represent consummate parasites, often covertly coopting host
resources to enable development and ultimately transmission to a new host. The overall …

Microbiology and pathogenesis of Chlamydia, Coxiella, and Rickettsia

M Bonazzi - Frontiers in Cellular and Infection Microbiology, 2024 - frontiersin.org
This Research Topic sheds light on the complex interplay between obligate intracellular
pathogens and their hosts, the innovative methods driving new discoveries, and the ongoing …

A coming of age story: Chlamydia in the post-genetic era

AJ Hooppaw, DJ Fisher - Infection and immunity, 2016 - Am Soc Microbiol
Chlamydia spp. are ubiquitous, obligate, intracellular Gram-negative bacterial pathogens
that undergo a unique biphasic developmental cycle transitioning between the infectious …

Chlamydia-host interaction and its pathogenic mechanism

Z Zhou, Y Liu, C Yang, HA Saka - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
These four families encompass obligate intracellular Gram-negative bacteria that infect
eukaryotic cells, from animals and insects to protozoa. All the Chlamydiales share a highly …

New advances in obligate intracellular bacteria: pathogenesis and host interactions

J Jiao, J Wang, J Fu - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Chlamydia) are an important and fascinating group of microorganisms, as they are often
pathogenic to humans and represent a significant public health burden worldwide (Fisher et …

Twenty years of research into Chlamydia-like organisms: a revolution in our understanding of the biology and pathogenicity of members of the phylum Chlamydiae

A Taylor-Brown, L Vaughan, G Greub… - FEMS Pathogens and …, 2015 - zora.uzh.ch
Chlamydiae are obligate intracellular bacteria that share a unique but remarkably conserved
biphasic developmental cycle that relies on a eukaryotic host cell for survival. Although the …

Advances in genetic manipulation of obligate intracellular bacterial pathogens

PA Beare, KM Sandoz, A Omsland… - Frontiers in …, 2011 - frontiersin.org
Infections by obligate intracellular bacterial pathogens result in significant morbidity and
mortality worldwide. These bacteria include Chlamydia spp., which causes millions of cases …

A minimal replicon enables efficacious, species-specific gene deletion in Chlamydia and extension of gene knockout studies to the animal model of infection using …

KA Fields, MD Bodero, KR Scanlon… - Infection and …, 2022 - Am Soc Microbiol
The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various
animals, including humans. Although chlamydial species share many aspects of the typical …

[PDF][PDF] Host cell death during infection with Chlamydia: a double-edged sword

BS Sixt - FEMS Microbiology Reviews, 2021 - academic.oup.com
The phylum Chlamydiae constitutes a group of obligate intracellular bacteria that infect a
remarkably diverse range of host species. Some representatives are significant pathogens …