Macrophages predominate the inflammatory landscape within multiple sclerosis (MS)
lesions, not only regarding cellularity but also with respect to the diverse functions this cell …

Objective Paraneoplastic neurologic disorders (PND) are autoimmune diseases associated
with cancer and ectopic expression of a neuronal antigen in a peripheral tumor. Patients …

The adoptive transfer of myelin-reactive T cells into wild-type hosts results in spinal cord
inflammation and ascending paralysis, referred to as conventional experimental …

Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …

Glial cells and central nervous system (CNS)-infiltrating leukocytes contribute to multiple
sclerosis (MS). However, the networks that govern crosstalk among these ontologically …

Multiple sclerosis (MS) is a chronic disease that is characterized by the inappropriate
invasion of lymphocytes and monocytes into the central nervous system (CNS), where they …

Background CXC chemokine ligand 13 (CXCL13) is frequently elevated in cerebrospinal
fluid (CSF) in a variety of inflammatory central nervous system (CNS) diseases, has been …

In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …

The receptor for colony stimulating factor 1 (CSF-1R) is important for the survival and
function of myeloid cells that mediate pathology during experimental autoimmune …

T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …