Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of
individuals worldwide. Although classically viewed as T-cell mediated disease, the role of …

Two distinct clinical phenotypes of experimental autoimmune encephalomyelitis are
observed in BALB interferon-γ knockout mice immunized with encephalitogenic peptides of …

The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in
response to three ligands, CXCL9, CXCL10, and CXCL11. Although these chemokines are …

Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which
is produced by oligodendrocytes (OLs). We performed single-cell transcriptomic analysis of …

Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple
sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …

Cases of progressive multifocal leukoencephalopathy can occur in patients treated with the
B cell depleting anti-CD20 antibody, rituximab, highlighting the importance of B cell …

Dendritic cells (DCs)—although absent from the healthy CNS parenchyma—rapidly
accumulate within brain and spinal cord tissue during neuroinflammation associated with …

Multiple sclerosis is considered to be initiated by a deregulated, myelin-specific T cell
response. However, the formation of inflammatory CNS lesions and the contribution of …

Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry
and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of …