At steady state, the CNS parenchyma has few to no lymphocytes and less potent Ag-
presentation capability compared with other organs. However, the meninges surrounding …

The recent (re) discovery of the meningeal lymphatic system has opened new theories as to
how immune cells traffic and interact with the central nervous system (CNS). While evidence …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

Highlights•Meninges are an immunologically active compartment regulating normal and
pathological brain function.•The extended meningeal lymphatics network ensures drainage …

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

In most organs of the body, immunological reactions involve the drainage of antigens and
antigen presenting cells (APCs) along defined lymphatic channels to regional lymph nodes …

The central nervous system (CNS) is considered to be an immunological privileged site.
However, inflammatory reactions in response to virus infections, in multiple sclerosis (MS) …