Hyper-Activated Pro-Inflammatory CD16+ Monocytes Correlate with the Severity of Liver Injury and Fibrosis in Patients with Chronic Hepatitis B

JY Zhang, ZS Zou, A Huang, Z Zhang, JL Fu, XS Xu… - PloS one, 2011 - journals.plos.org
Background Extensive mononuclear cell infiltration is strongly correlated with liver damage
in patients with chronic hepatitis B virus (CHB) infection. Macrophages and infiltrating …

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

A Tan-Garcia, LE Wai, D Zheng, E Ceccarello, J Jo… - Journal of …, 2017 - Elsevier
Background & Aims Liver inflammation is key in the progression of chronic viral hepatitis to
cirrhosis and hepatocellular carcinoma. The magnitude of viral replication and the specific …

Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis

J Li, SJ Qiu, WM She, FP Wang, H Gao, L Li, CT Tu… - PloS one, 2012 - journals.plos.org
Background Hepatitis B virus-related liver fibrosis (HBV-LF) always progresses from
inflammation to fibrosis. However, the relationship between these two pathological …

Increased CD86 but Not CD80 and PD-L1 Expression on Liver CD68+ Cells during Chronic HBV Infection

EA Said, I Al-Reesi, M Al-Riyami, K Al-Naamani… - PloS one, 2016 - journals.plos.org
Background The failure to establish potent anti-HBV T cell responses suggests the absence
of an effective innate immune activation. Kupffer cells and liver-infiltrating monocytes …

Imbalance of interleukin‐17‐producing CD 4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus‐related acute‐on‐chronic liver …

GL Zhang, DY Xie, BL Lin, C Xie, YN Ye… - Journal of …, 2013 - Wiley Online Library
Abstract Background and Aim Although regulatory T cells (T reg) and interleukin‐17‐
producing CD 4 T cells (T h17) have been demonstrated to play opposing roles in …

Increased Th17 cells and interleukin-17 contribute to immune activation and disease aggravation in patients with chronic hepatitis B virus infection

B Yang, Y Wang, C Zhao, W Yan, H Che, C Shen… - Immunology …, 2013 - Elsevier
T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of
hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to …

Increased Th17 cells contribute to disease progression in patients with HBV‐associated liver cirrhosis

HQ Sun, JY Zhang, H Zhang, ZS Zou… - Journal of viral …, 2012 - Wiley Online Library
T helper (Th) 17 cells have been demonstrated to participate in the pathogenesis of HBV‐
associated liver damage. However, little is known regarding the immunopathogenic role of …

Treg/Th17 cell balance in patients with hepatitis B virus‐related acute‐on‐chronic liver failure at different disease stages

NH Tan, B Chen, J Peng, S Du - BioMed Research International, 2021 - Wiley Online Library
Background. T‐helper 17 (Th17) and CD4+ CD25+ T‐regulatory (Treg) cells play important
roles in the pathogenesis of hepatitis B virus‐related acute‐on‐chronic liver failure (HBV …

Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection

S Faure-Dupuy, M Delphin, L Aillot, L Dimier… - Journal of …, 2019 - Elsevier
Background & Aims Liver macrophages can be involved in both pathogen clearance and/or
pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) …

Elevated circulating CD14lowCD16+ monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization

A Peng, P Ke, R Zhao, X Lu, C Zhang, X Huang… - Clinical and …, 2016 - Springer
Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which
monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell …