The vastness of clinical data and the progressing specialization of medical knowledge may
lead to misinterpretation of medication efficacy. To show a realistic perspective on drug …

Promising evidence from clinical studies of drug effects does not always translate to
improvements in patient outcomes. In this review, we discuss why early evidence is often ill …

Real-world studies have become increasingly important in providing evidence of treatment
effectiveness in clinical practice. While randomized clinical trials (RCTs) are the “gold …

How should health care professionals choose among the many therapies claimed to be
efficacious for treating specific disorders? The practice of evidence-based medicine …

Comparative‐effectiveness research (CER) aims to produce actionable evidence regarding
the effectiveness and safety of medical products and interventions as they are used outside …

Purpose To provide an overview of and discuss newly authorised medicines with an
improved efficacy. Methods This analysis focussed on new medicines with an improved …

THE CENTRAL THEME OF THE INSTITUTE OF MEDICINE report on the US drug safety
system was the need for a life cycle approach to drug evaluation: both the benefits and the …

Background There have been ongoing efforts to understand when and how data from
observational studies can be applied to clinical and regulatory decision making. The …

Objective To identify and assess the methods for estimating comparative clinical
effectiveness for novel pharmaceutical products licensed on the basis of nonrandomized …

Physicians and insurers need to weigh the effectiveness of new drugs against existing
therapeutics in routine care to make decisions about treatment and formularies. Because …