NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation

M Chattopadhyay, S Goswami, DB Rodes, R Kodela… - Cancer letters, 2010 - Elsevier
NO-NSAIDs are promising anticancer drugs, comprising an NSAID, an NO-releasing moiety,
and a spacer linking them. Although the effect of NO-NSAIDs on a wide variety of signaling …

Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action

JL Williams, P Ji, N Ouyang, L Kopelovich… - Experimental cell …, 2011 - Elsevier
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for cancer prevention. Although
studied extensively, its molecular targets and mechanism of action are still unclear. S …

NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action

B Rigas, JL Williams - Nitric Oxide, 2008 - Elsevier
Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) consist of a
conventional NSAID to which an NO-releasing moiety is attached covalently, often via a …

Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines*

M Rosetti, A Tesei, P Ulivi, F Fabbri, I Vannini… - Apoptosis, 2006 - Springer
Although non steroidal antiinflammatory drugs (NSAIDs) have been shown to be effective as
chemopreventive agents, important side-effects limit their clinical use. A promising novel …

NO-releasing NSAIDs and colon cancer chemoprevention: a promising novel approach

B Rigas, JL Williams - International journal of oncology, 2002 - spandidos-publications.com
The chemoprevention of colon cancer, the second leading cause of cancer-related deaths in
the United States, has been pursued actively during the last two decades. Methodological …

Novel agents for cancer prevention based on nitric oxide

B Rigas - Biochemical Society Transactions, 2007 - portlandpress.com
NO (nitric oxide) biology has provided the impetus for the development of anticancer agents
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …

Development of novel agents based on nitric oxide for the control of colon cancer1

V Kozoni, T Rosenberg, B Rigas - Acta Pharmacologica Sinica, 2007 - Wiley Online Library
Nitric oxide‐donating nonsteroidal anti‐inflammatory drugs (NO‐NSAIDs) represent a novel
class of compounds that hold promise as agents for the control of colon cancer. They are …

Nitric-oxide-donating NSAIDs as agents for cancer prevention

B Rigas, K Kashfi - Trends in Molecular Medicine, 2004 - cell.com
Nitric-oxide-donating nonsteroidal anti-inflammatory drugs (NO–NSAIDs), which consist of
an NSAID with an NO-donating moiety covalently attached to it, promise to contribute …

NO-donating aspirin inhibits the activation of NF-κB in human cancer cell lines and Min mice

JL Williams, P Ji, N Ouyang, X Liu, B Rigas - Carcinogenesis, 2008 - academic.oup.com
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the control of cancer, whose
mechanism of action remains unclear. NF-κB is an important signaling molecule in the …

NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property …

RK Yeh, J Chen, JL Williams, M Baluch… - Biochemical …, 2004 - Elsevier
The novel nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs),
consisting of a traditional NSAID to which a NO releasing moiety is covalently attached, may …